What Accupril is and what it is used for
Accupro contains quinapril, which is one of a group of medicines called angiotensin converting enzyme (ACE) inhibitors. ACE inhibitors work by widening blood vessels in the body, which can reduce the pressure in the vessels. Accupro is used to treat high blood pressure, or to help treat heart failure. You must talk to a doctor if you do not feel better or if you feel worse
How to take Accupril
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. The recommended dose of Accupro is: Adults For treatment of hypertension (high blood pressure) the starting dose is usually 10 mg a day, which may be increased gradually up to a maximum of 80 mg a day. For the treatment of heart failure, if you are also taking water tablets (diuretics) to treat your high blood pressure, you are aged 65 or over, or you have kidney disease, the starting dose is usually 2.5 mg, which may be increased up to a maximum of 40 mg a day. Accupro tablets should be taken either once or twice a day. Whatever dose you have been prescribed, follow your doctor's instructions exactly and never change the dose yourself. The tablets can be taken with or without food. Swallow the tablets whole with water. Do not chew, divide or crush the tablets. The score line is only there to help you break the tablet if you have difficulty swallowing it whole. Use in children and adolescents Accupro should not be used in children and adolescents under 18 years of age. If you take more Accupro than you should Taking too many tablets at once may make you unwell. Tell your doctor or go to your nearest hospital casualty department immediately. Take along any tablets that are left, the packaging and the label so that the hospital staff can easily tell what medicine you have taken. If you forget to take Accupro If you forget to take a dose, miss out the forgotten dose completely and take the next dose at the normal time. Do not take a double dose to make up for a forgotten dose. If you stop taking Accupro Do not stop taking your tablets or alter the dose you are currently taking without seeing your doctor first. It is important to keep taking your tablets as they help to control your blood pressure. Do not wait until your tablets are finished before seeing your doctor. If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Possible side effects
Like all medicines, this medicine can cause side effects although not everybody gets them.
STOP taking Accupro and tell your doctor immediately if you experience any of the following symptoms
after taking this medicine. These symptoms can be serious.
• Severe allergic (anaphylactoid) reaction to this medicine. The symptoms include swelling of the face, tongue and throat which cause great difficulty breathing and angioedema (swelling of the deeper layer of the skin caused by a build-up of fluid).
• Severe abdominal pain causing you to be sick, resulting from inflammation of the wall of the bowel (intestinal angioedema).
• Severe abdominal pain that may spread to the back accompanied with feeling very unwell which may be a symptom of pancreatitis.
• Chest pain, tightness of the chest, shortness of breath, wheezing or trouble breathing, which may be a symptom of angina or a heart attack and an irregular or rapid heartbeat (palpitations).
• Weakness of arms, legs or face or problems speaking and visual disturbance which may be symptoms of a possible stroke.
• Sudden severe headache, seizures, loss of coordination, loss of balance (cerebrovascular accident).
• Skin rash, rawness, irritation, itching, hives, blistering, peeling and scaling.
• Red or purple skin rash, skin pain, hives, blistering of the skin and mouth, nose, eyes, genitals, facial and tongue swelling developing after a fever, flu like symptoms (Stevens Johnson Syndrome).
• Feeling faint, particularly when suddenly standing up. This may mean your blood pressure is too low (hypotension). This is more likely to occur if you have been taking diuretics (water tablets), other blood pressure medication in addition to Accupro, alcohol or if you are dehydrated or on dialysis. If you feel light headed or faint, lie down until this feeling passes.
• Severe sore throat or severe mouth ulcers, particularly if you suffer from kidney problems or collagen vascular disease. This may mean you do not have enough of certain white blood cells (neutropenia/agranulocytosis), which may lead to increased risk of infection or fever.
• Tightness of the chest, shortness of breath, wheezing or trouble breathing.
• Yellowing of the skin or the whites of the eyes (jaundice). The following side-effects have also been reported in patients with high blood pressure being treated with Accupro:
Common: may affect up to 1 in 10 people
• increased potassium levels in the blood
• coughing; throat infection
• nasal stuffiness and/or runny nose (rhinitis)
• feeling or being sick
• tiredness; weakness; lack of energy
• sensation of tickling, pricking or burning on the skin
• back pain
• low blood pressure
• pain in the muscle
• increased creatinine and urea nitrogen in the blood
Uncommon: may affect up to 1 in 100 people
• depression; nervousness; confusion
• widening of the blood vessels
• fluid retention in the body
• rapid heartbeat (tachycardia)
• reduced vision (not correctable by glasses or contact lenses)
• ringing or noises in the ears
• spinning of the head or dizziness due to problems with the inner ear
• dry mouth or throat
• excessive sweating
• rash on the skin
• failure/inability to achieve erection in males
• protein in urine, urinary tract infection, reduced kidney function
• inflammation of your sinuses (sinusitis), bronchitis, upper respiratory tract infection
Rare: may affect up to 1 in 1,000 people
• taste disturbances
• soreness of the tongue
• disorders of balance
• swelling of the lungs from an increase in eosinophils, a type of white blood cell (eosinophilic pneumonitis)
Very rare: may affect up to 1 in 10,000 people
• blurring of vision
• swelling of the walls of the bowels (intestines). Symptoms include abdominal pain, nausea, vomiting and intestinal cramps (intestinal angioedema)
Not known: frequency cannot be estimated from the available data
• abnormal breakdown of red blood cells
• bruising or a purple or red rash (purpura)
• abdominal pain caused by inflammation of the liver or blocked bile ducts
• decreased numbers of white blood cells or decrease in blood platelets (thrombocytopenia) which may result in bruising or easy bleeding; low numbers of red blood cells (anaemia)
• decreased sodium concentrations in the blood
• hair loss
• sensitivity of the skin to light Accupro may cause certain changes in your blood and your doctor may do blood tests to monitor this. If you notice bruising, feeling very tired or if you are diabetic and notice sugar levels rising let your doctor know so blood tests can be arranged if necessary.
Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.
How to Store Accupril
Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the carton and blister strip after EXP. The expiry date refers to the last day of that month. Do not store above 25°C. Store in the original package in order to protect from moisture. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
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