Actoplus Met
(Pioglitazone Hydrochloride/Metformin Hydrochloride)

Prescription Settings Edit

Brand Name Choices

Actoplus Met 15/850mg
Actoplus Met 15/850mg

Marketed as Competact in United Kingdom

Pioglitazone Hydrochloride/Metformin Hydrochloride

Manufactured by Takeda UK Ltd

Product of United Kingdom

Dispensed by a licensed pharmacy in the United Kingdom

Prescription Required

Parallel Import

Generic Choices

No generic medication is available for Actoplus Met (Pioglitazone Hydrochloride/Metformin Hydrochloride)

What Actoplus Met is and what it is used for

Competact contains pioglitazone and metformin. It is an anti-diabetic medicine used in adults to treat type 2 (non-insulin dependent) diabetes mellitus when treatment with metformin alone is not sufficient. This type 2 diabetes usually develops in adulthood particularly as a result of the person being overweight and where the body either does not produce enough insulin (a hormone that controls blood sugar levels), or cannot effectively use the insulin it produces. Your doctor will check whether Competact is working 3 to 6 months after you start taking it. Competact helps control the level of sugar in your blood when you have type 2 diabetes by helping your body make better use of the insulin it produces.

How to take Actoplus Met

Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. The recommended dose is one tablet taken twice daily. If necessary your doctor may tell you to take a different dose. If you have reduced kidney function, your doctor may prescribe a lower dose, which may need to be given as separate tablets of pioglitazone and metformin. You should swallow the tablets with a glass of water. You may take your tablets with or just after food to reduce the chance of an upset stomach. If you are following a special diet for diabetes, you should continue with this while you are taking Competact. Your weight should be checked at regular intervals; if your weight increases, inform your doctor. Your doctor will ask you to have blood tests periodically during treatment with Competact. This is to check that your liver is working normally. At least once a year (more often if you are elderly or have kidney problems) your doctor will check that your kidneys are working normally. If you take more Competact than you should If you accidentally take too many tablets, or if someone else or a child takes your medicine, talk to a doctor or pharmacist immediately. Your blood sugar could fall below the normal level and can be increased by taking sugar. It is recommended that you carry some sugar lumps, sweets, biscuits or sugary fruit juice. If you have taken more Competact that you should have, you may experience lactic acidosis (see section “Risk of lactic acidosis”). If you forget to take Competact Take Competact daily as prescribed. However if you miss a dose, skip the missed dose and just carry on with the next dose as normal. Do not take a double dose to make up for a forgotten tablet. If you stop taking Competact Competact should be used every day to work properly. If you stop using Competact, your blood sugar may go up. Talk to your doctor before stopping this treatment. If you have any further questions on the use of this medicine ask your doctor or pharmacist.

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. Competact may cause a very rare (may affect up to 1 in 10,000), but very serious side effect called lactic acidosis (see section “Risk of lactic acidosis”). If this happens you must stop taking Competact and contact a doctor or the nearest hospital immediately, as lactic acidosis may lead to coma. Bladder cancer has been experienced uncommonly (may affect up to 1 in 100 people) in patients taking Competact. Signs and symptoms include blood in your urine, pain when urinating or a sudden need to urinate. If you experience any of these, talk to your doctor as soon as possible. Broken bones have been reported commonly (may affect up to 1 in 10 people) in female patients taking Competact and have also been reported in male patients (frequency cannot be estimated from the available data) taking Competact. If you experience this side effect, talk to your doctor as soon as possible. 5 Blurred vision due to swelling (or fluid) at the back of the eye (macular oedema) has been reported (frequency cannot be estimated from available data). If you experience these symptoms for the first time talk to your doctor as soon as possible. Also, if you already have blurred vision and the symptoms get worse, talk to your doctor as soon as possible. Allergic reactions have been reported with frequency not known (cannot be estimated from available data) in patients taking Competact. If you have a serious allergic reaction, including hives and swelling of the face, lips, tongue, or throat that may cause difficulty in breathing or swallowing, stop taking this medicine and talk to your doctor immediately.

The following side effects have been experienced by some patients taking Competact:

Very common (may affect more than 1 in 10 people)
•stomach ache
•feeling sick (nausea)
•loss of appetite

Common (may affect up to 1 in 10 people)
•localised swelling (oedema)
•weight gain
•respiratory infection
•abnormal vision
•joint pain
•blood in urine
•reduction in blood count (anaemia)
•taste disturbance

Uncommon (may affect up to 1 in 100 people)
•inflammation of the sinuses (sinusitis)
•difficulty sleeping (insomnia)

Very rare (may affect up to 1 in 10,000)
•decrease in amount of vitamin B12 in the blood
•redness of the skin
•itchy skin
•raised and itchy rash (hives)

Not known (frequency can not be estimated from the available data)
•inflammation of the liver (hepatitis)
•liver does not work as well as it should (changes in liver enzymes)

Reporting of side effects If you get any side effects talk to your doctor. This includes any side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme. Website: or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.

How to Store Actoplus Met

Keep this medicine out of the sight and reach of children. 6 Do not use this medicine after the expiry date which is stated on the carton and the blister after “EXP”. The expiry date refers to the last day of that month. This medicine does not require any special storage conditions. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

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