COVID-19 SERVICE UPDATE – JANUARY 2021

HAPPY NEW YEAR AND ALL THE BEST IN 2021


Shipping Update

We are now seeing improvements in our shipping times. However, things are not yet back to normal and there are still some delays occurring.

Our normal shipping time averages 1 - 2 weeks. Shipments may potentially take an additional 2 – 4 weeks to arrive, depending on the source country of your order. Shipments from the United Kingdom and Canada are generally quicker than from other countries.

Please note that these times are averages and individual shipping times will vary. We highly recommend that you place your order at least 2 – 4 weeks or more ahead of your normal reorder time to avoid running out of your medication.

These delays are temporary, and we thank the shipping and delivery personnel who are working hard for all of us during this global crisis.

Please Note: We have resumed our normal 30-Day Shipping Guarantee. We will provide updates as the situation changes.

Call Center

Our call center hours of operation are 6:00 am – 9:00 pm Central Time on Monday to Friday, and 7:00 am – 7:00 pm Central Time on Saturday and Sunday.

If you are experiencing increased hold times or are calling outside of these hours, please leave us a message or send us an email and we will get back to you as soon as we can. Due to increased demand on telephone networks worldwide, you may experience some intermittent connection problems. If this happens our agents will call you back.

Our Commitment

If you have any questions about any changes in our service please do not hesitate to contact us. Our staff are working tirelessly to ensure the timely fulfillment and delivery of all orders. The health and safety of our customers and staff is our highest priority and we remain committed to providing service at the highest level.

We appreciate your business and thank you for your continued support.


Management and Staff
Medix Pharmacy

Ambisome
(Amphotericin B Liposomal)

Prescription Settings Edit

Brand Name Choices

Ambisome 50mg
Ambisome 50mg Injection

Amphotericin B Liposomal

Manufactured by Gilead Sciences Ltd

Product of United Kingdom

Dispensed by a licensed pharmacy in the United Kingdom

Prescription Required

Parallel Import

Generic Choices

No generic medication is available for Ambisome (Amphotericin B Liposomal)

What Ambisome is and what it is used for

AmBisome is an antifungal antibiotic. The active ingredient in AmBisome is amphotericin B. AmBisome is given as an infusion into a vein (a drip) in hospital by a doctor or nurse.AmBisome is used to treat serious infections caused by fungi:
• Fungal infections of one or more deep organs of the body.
• Suspected fungal infections in patients with a raised temperature and neutropenia. Neutropenia is a reduced number of white blood cells called neutrophils. These are important in fighting infections. Neutropenia can be a side effect of cancer treatments. Before you are given AmBisome your doctor will check that your fever is not due to bacteria or viruses. You will probably have had one or more antibiotics already. A fever which continues despite treatment may be due to a fungal infection. It’s difficult to confirm this with current tests, however.
• Visceral leishmaniasis, a disease caused by a parasite.

How to take Ambisome

AmBisome is always given to you by a doctor or nurse. It is given into a vein (a drip). AmBisome must not be given by any other method. To prepare the infusion AmBisome must be dissolved in sterile water for injection and then diluted with a solution containing dextrose. AmBisome must not be mixed with saline (salt) solutions or with other medicinal products or electrolytes. AmBisome is not interchangeable with other amphotericin products. Before your first treatment Before your first treatment your doctor may give you a small amount of AmBisome. They will then wait for approximately 30 minutes to see whether you have an allergic reaction, before continuing the infusion of the full dose. Use in adults Your dose of AmBisome will depend on your body weight. Fungal infections of one or more deep organs of the body: Treatment is normally started at 1 mg per kg of body weight, every day over 2 to 4 weeks. Your doctor may decide to increase the amount you receive to as high as 3 mg per kg of body weight. For mucormycosis the starting dose is normally 5 mg per kg of body weight per day. The duration of therapy will be determined on an individual basis by your Doctor. Suspected fungal infections in patients with a raised temperature and neutropenia: The recommended daily dose is 3 mg per kg of body weight, per day. AmBisome will be given to you until your temperature is normal for 3 days in a row. However, AmBisome must not be given for more than 42 days in a row. Visceral leishmaniasis: You may be given a total dose of between 21 and 30 mg per kg of body weight, over a period of 10 to 21 days. Your doctor will decide on the amount of AmBisome you will receive and over how many days it will be given. Use in children and adolescents AmBisome has been used to treat children. The dose of AmBisome for a child is calculated per kg of body weight in the same way as for adults. AmBisome is not recommended in babies under 1 month old. Use in elderly patients No change in dose or frequency of infusion is needed for elderly patients. Use in patients with kidney problems AmBisome has been given to patients with kidney problems at doses ranging from 1 to 5 mg per kg of body weight per day. No change in dose or frequency of infusion is required. Your doctor or nurse will take regular blood samples to test for changes in kidney function during AmBisome treatment. How long will the infusion take?Normally the infusion will take 30 to 60 minutes. For doses greater than 5 mg per kg of body weight per day, the infusion could take up to 2 hours. If you receive a higher dose of AmBisome than you should You should tell your doctor immediately if you think you received too much AmBisome. If you have any further questions on the use of this product, ask your doctor.

Possible side effects

Like all medicines, AmBisome can cause side effects, although not everybody gets them. Side effects during the infusion You may get side effects during the infusion:


Very common (These can affect more than 1 in every 10 people): fever, chills, and shivering.
• Less frequent infusion-related side effects include: chest tightness, chest pain, breathlessness, difficulty breathing (possibly with wheezing), flushing, a faster heart rate than normal, low blood pressure and musculoskeletal pain (described as joint pain, back pain, or bone pain). These side effects clear up quickly when the infusion is stopped. These reactions may not happen with future infusions of AmBisome or with a slower infusion (over 2 hours). Your doctor may give you other medicines to prevent infusion-related reactions, or to treat the symptoms if you do get them. If you have a severe infusion-related reaction, your doctor will stop the AmBisome infusion and you should not receive this treatment in the future.

Very common side effects These can affect more than 1 in every 10 people:
• Low blood potassium levels, leading to feeling tired, confused, having muscle weakness or cramps
• Feeling sick or being sick
• Fever, chills or shivering.

Common side effects These can affect up to 1 in every 10 people:
• Low magnesium, calcium or sodium blood levels, leading to feeling tired, confused, muscle weakness or cramps
• High blood sugar levels
• Headache
• A faster heart rate than normal
• Widening of the blood vessels, causing low blood pressure and flushing
• Breathlessness
• Diarrhoea
• Stomach (abdominal) pain
• Rash
• Chest pain
• Back pain
• Abnormal results for liver or kidney function showing up in blood tests or urine tests.

Uncommon side effects These can affect up to 1 in every 100 people:
• Bleeding into the skin, unusual bruising and bleeding for a long time after injury
• Severe allergic (anaphylactoid) reaction
• Fits or seizures (convulsions)
• Difficulty breathing, possibly with wheezing.

Other side effects It is not known how frequently these side effects occur:
• Anaemia (low red blood cell levels), with symptoms of excessive tiredness, being out of breath after light activity, and a pale complexion
• Severe allergic (anaphylactic) or sensitivity reactions
• Heart attacks and heart rhythm changes
• Kidney failure and kidney problems. Signs include tiredness and passing less urine
• Severe swelling of the skin around the lips, eyes or tongue.
• Breakdown of muscle
• Bone pain and joint pain Interference with Phosphorus blood test results. False readings showing an increase in the levels of phosphate in your blood may occur when samples from patients receiving AmBisome are analyzed using a specific system called a PHOSm assay. If your test results show high levels of phosphate, then further analysis using a different system may be necessary to confirm the results.

Reporting of side effects If you get any side effects, talk to your doctor. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the nationnal reporting system: United Kingdom Yellow Card Scheme Website: www.mhra.gov.uk/yellowcard

How to Store Ambisome

AmBisome is stored in the hospital pharmacy. Keep this medicine out of the sight and reach of children. Do not use AmBisome after the date which is stated on the label after {EXP}. The expiry date refers to the last day of the month. Do not store above 25°C. Do not store partially used vials for future patient use. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help to protect the environment.

Fast Shipping

2 to 3 weeks on average

The average shipping time is 2 weeks in North America and 4 weeks internationally. We offer free shipping on all orders shipped to North America. Shipping is a flat rate of $20.00 for all other countries.

Price Match Guarantee

If you have been prescribed medication by your doctor and cannot afford the high price at your local pharmacy, Medix Pharmacy is the solution for you. All orders are backed with a price match and satisfaction guarantee.

Your Trusted Pharmacy Referral Service

Medix Pharmacy is an international pharmacy referral service. With a network of licensed pharmacy partners in Canada, United Kingdom, Australia, and New Zealand, we are able to help you lower the costs of your medications.

Our pharmacy partners are all thoroughly vetted and qualified to ensure that the medication you receive is cost effective, safe and effective. Because we only work with licensed pharmacies, you can rest assured that your medication is safe, effective, and genuine.

  • Free standard delivery to your door, to any international address
  • Option to add Tracked Deliveries
  • Handy reminders to re-order so you do not run out
  • Professional & Knowledgeable Customer Services Team
  • Save time, with no need for repeated trips to your physician or local drugstore

With a dedicated customer service team, free standard shipping, and a record of providing significant saving for our customers, we believe that you do not need to compromise quality or safety in your search for value.

If you are unable to find your prescribed medicine on our website, please fill out the form below and we will confirm pricing and availability within 1 business day. You may also call us at 1-866-500-6633 and one of our patient care representatives will be happy to assist you.