Amiloride

(Amiloride)

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  • Amiloride Overview

    Amiloride is used with other "water pills"/diuretics (such as furosemide, thiazide diuretics like hydrochlorothiazide) to treat high blood pressure (hypertension), heart failure, or extra fluid in the body (edema). Amiloride also helps to treat or prevent low blood potassium levels caused by the other diuretics. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Amiloride is called a "water pill" (diuretic) and causes your body to get rid of extra salt and water while also preventing the kidneys from getting rid of too much potassium.

  • Amiloride Warnings

    Amiloride can cause high potassium levels (hyperkalemia). This effect is more likely to occur in older adults and in patients with kidney disease, diabetes, or a serious illness. Potassium levels must be closely monitored on a regular basis while taking Amiloride. If not treated, very high potassium levels can sometimes be fatal. Tell your doctor right away if you develop any symptoms of high potassium levels, including muscle weakness, slow/irregular heartbeat, numb/tingling skin.

  • How to Use Amiloride

    Take Amiloride by mouth with food as directed by your doctor, usually once daily. If you take Amiloride too close to bedtime, you may need to wake up to urinate. It is best to take Amiloride at least 4 hours before your bedtime. If you have any questions about how and when to take Amiloride, ask your doctor or pharmacist. The Dosage of Amiloride is based on your medical condition and response to treatment. Use Amiloride regularly in order to get the most benefit from it. To help you remember, take it at the same time each day. Keep taking Amiloride even if you feel well. Most people with high blood pressure do not feel sick. Tell your doctor if your condition does not improve or if it worsens (such as your blood pressure readings remain high or increase).

  • Amiloride Precautions

    Before taking amiloride, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Amiloride may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using Amiloride, tell your doctor or pharmacist your medical history,untreated salt/mineral imbalance (such as high potassium, low sodium level), kidney disease, liver disease, diabetes, dehydration. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Amiloride may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis). Dehydration from too much sweating, vomiting, or diarrhea can also lower your blood pressure and worsen dizziness. Drink plenty of fluids to prevent these effects and dehydration. If you are on restricted fluid intake, consult your doctor for further instructions. Contact your doctor if you are unable to drink fluids or if you have diarrhea/vomiting that doesn't stop. Amiloride may increase the potassium levels in your blood. Limit foods high in potassium such as bananas and orange juice. Consult your doctor or pharmacist before using any products containing potassium (such as potassium supplements, salt substitutes). During pregnancy, Amiloride should be used only when clearly needed. Discuss the risks and benefits with your doctor. It is unknown if Amiloride passes into breast milk. Discuss the risks and benefits with your doctor before breast-feeding.

  • Amiloride Misdose

    If you miss a dose of Amiloride, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

  • Amiloride Interactions

    See also Precautions section. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.lithium, sodium phosphate products, other products that may increase potassium levels (such as eplerenone, tacrolimus, cyclosporine, birth control pills containing drospirenone, potassium-sparing diuretics like spironolactone/triamterene, ACE inhibitors like benazepril/captopril, angiotensin receptor antagonists like losartan/valsartan). Some products have ingredients that could raise your blood pressure or worsen your heart failure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen). Amiloride may interfere with certain laboratory tests (including glucose tolerance testing), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use Amiloride.

  • Amiloride Side Effects

    Headache, dizziness, nausea, vomiting, loss of appetite, stomach/abdominal pain, gas, or diarrhea may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that Amiloride has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using Amiloride do not have serious side effects. When given with other diuretics, amiloride may cause dehydration and electrolyte imbalance.very dry mouth, extreme thirst, muscle cramps, weakness, fast heartbeat, severe dizziness, confusion, fainting, seizures. Tell your doctor right away if you have any serious side effects,nausea/vomiting that doesn't stop, signs of kidney problems (such as change in the amount of urine), yellowing eyes/skin, dark urine. A very serious allergic reaction to Amiloride is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction,rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

  • Amiloride Storage

    Store at room temperature away from light and moisture. Protect from freezing. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard Amiloride when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

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