Brand Name Choices
What Arthrotec is and what it is used for
Arthrotec helps to relieve the pain and swelling of rheumatoid arthritis and osteoarthritis, and may help to protect patients at risk of irritation or ulceration of the stomach or intestines. Arthrotec contains diclofenac and misoprostol. Diclofenac belongs to a group of medicinal products called Non-Steroidal Anti-Inflammatory drugs (NSAIDs). Although NSAIDs relieve the pain, they can reduce the amount of natural protective substances called prostaglandins in the stomach lining. This means that NSAIDs can lead to stomach upsets or stomach ulcers. Arthrotec also contains misoprostol which is very similar to these prostaglandins and may help protect your stomach.
How to take Arthrotec
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. The recommended dose is one tablet two or three times a day, or as directed by your doctor. Arthrotec should be swallowed whole with a drink of water (not chewed), taken during or after mealtimes. In the elderly and patients with liver or kidney disorders, your doctor may want to monitor you more closely. No change in dose is needed. Use in children: Arthrotec is for adults only, it is not for use in children (under 18 years). If you take more Arthrotec than you should You should not take more tablets than your doctor tells you to. If you take too many tablets contact your doctor, pharmacist or hospital as soon as possible, and take your medicine with you. If you forget to take Arthrotec If you forget to take a tablet, take it as soon as you remember. Do not take a double dose to make up for a forgotten dose. If you stop taking Arthrotec Do not stop taking Arthrotec unless your doctor tells you to. If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
If you are worried about side effects, ask your doctor. It is important that you know what can happen, so
that you can take action if Arthrotec does have a side effect. Arthrotec sometimes causes side effects but
these usually go away during treatment as your body gets used to the medicine.
If any of the following happen, stop taking Arthrotec and tell your doctor immediately:
If you have
• Weakness of or inability to move one side of body, slurred speech (stroke) or chest pain (heart attack) – the occurrence is uncommon
• Shortness of breath – the occurrence is uncommon
• Severe stomach pain or any sign of bleeding or rupture in the stomach or intestines, such as passing black or bloodstained stools, or vomiting blood – this occurs very rarely
• A serious skin reaction such as rash, blistering or peeling of the skin (Stevens-Johnson syndrome, exfoliative dermatitis and toxic epidermal necrolysis) – this occurs very rarely
• Heart failure, chest pain, palpitations (awareness of your heartbeat) – this occurs very rarely
• A serious allergic reaction such as skin rash, swelling of the face, wheezing or difficulty breathing (anaphylactic shock) – this occurs rarely
• Jaundice (your skin or the whites of your eyes look yellow) – this occurs rarely
• Arthrotec can cause a decrease in a type of white blood cell (these help protect the body from infection and disease) and lead to infections with symptoms like chills, sudden fever, sore throat, or flu-like symptoms. Immediately contact your doctor if any of these symptoms develop – it is not known how often this occurs
• Reduction in the number of blood platelets (increased chance of bleeding or bruising) – it is not known how often this occurs
• If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet.
Very common: may affect more than 1 in 10 people
• Stomach ache, diarrhoea, nausea (feeling sick), indigestion Diarrhoea is the most common problem and is occasionally severe. You have less chance of getting diarrhoea if you take Arthrotec with food. If you use an antacid (something to reduce acid in the stomach) you should avoid antacids with magnesium in them as these may make diarrhoea worse. Your pharmacist can help you choose a suitable antacid. If this diarrhoea continues and is severe tell your doctor.
Common: may affect up to 1 in 10 people
• Rash, itching
• Vomiting, wind, constipation, burping, gastritis (indigestion, stomach ache, vomiting)
• Ulcers in the stomach or intestines
• Headache, dizziness
• Difficulty sleeping
• Changes in blood tests relating to the liver
• Inflammation of the digestive tract, including the intestines, such as nausea, diarrhoea, abdominal pain
• Abnormal formation of foetus
Uncommon: may affect up to 1 in 100 people
• Swelling of the mouth
• Abnormal or unexpected bleeding from the vagina, menstrual disturbances
• Reduction in the number of blood platelets (increased chance of bleeding or bruising)
• Purpura (purple spots on the skin)
• Urticaria (raised itchy rash)
• Infection of the vagina (itching, burning, soreness, pain especially during intercourse and/or urination)
• Blurred vision
• High blood pressure
• Menstrual disorders such as usually heavy or light bleeding, or delayed periods
• Chills or fever
Rare: may affect up to 1 in 1,000 people
• Inflammation of the liver (possible yellow discoloration of skin, headache, fever, chills, general weakness)
• Inflammation of the pancreas, which causes severe pain in the abdomen and back
• Inflammation of the lung such as coughing, increased sputum
• Breast pain
Very rare: may affect up to 1 in 10,000 people
• Severe liver disorders including liver failure
Not known: frequency cannot be estimated from the available data
• Damage to the gullet
• Worsening of ulcerative colitis or Crohn’s disease (inflammation of the intestines)
• Kidney or liver problems
• Allergic reaction, including asthma, breathing problems, itching, hair loss, inflamed blood vessels (can cause fever, aches, purple blotches)
• Symptoms of meningitis (stiff neck, headache, nausea (feeling sick), vomiting, fever or loss of consciousness)
• Fluid build-up in the body that can cause swollen ankles and legs
• Vomiting blood
• Psychotic reactions (mental disorder that features loss of contact with reality)
• Swelling of the tongue, mouth ulcers, dry mouth
• Depression, feeling anxious, mood swings, irritability, memory problems, feeling confused, feeling shaky, drowsiness, tiredness
• Difficulty seeing, ringing in the ears, changes in the way things taste
• Increased sensitivity to light
• Loss of appetite
• Abnormal contractions of the womb, rupture in the womb, retained placenta after giving birth, a life-threatening reaction in the mother due to the passage of amniotic fluid (fluid covering the fetus) or other foetal material into the maternal blood stream, bleeding in the womb, miscarriage, death of the unborn baby, premature birth
• Low blood pressure
• Anaemia (low number of red blood cells) which can lead to pale skin and cause weakness or breathlessness
• Painful menstrual/period cramps
• Decreased fertility in females
Reporting of side effects If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.
How to Store Arthrotec
Keep this medicine out of the sight and reach of children. Do not store above 25°C. Store in the original packaging. Do not use this medicine after the expiry date which is stated on the blister and carton. The expiry date refers to the last day of that month. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
2 to 3 weeks on average
The average shipping time is 2 weeks in North America and 4 weeks internationally. We offer free shipping on all orders shipped to North America. Shipping is a flat rate of $20.00 for all other countries.
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