COVID-19 SERVICE UPDATE – JANUARY 2021

HAPPY NEW YEAR AND ALL THE BEST IN 2021


Shipping Update

We are now seeing improvements in our shipping times. However, things are not yet back to normal and there are still some delays occurring.

Our normal shipping time averages 1 - 2 weeks. Shipments may potentially take an additional 2 – 4 weeks to arrive, depending on the source country of your order. Shipments from the United Kingdom and Canada are generally quicker than from other countries.

Please note that these times are averages and individual shipping times will vary. We highly recommend that you place your order at least 2 – 4 weeks or more ahead of your normal reorder time to avoid running out of your medication.

These delays are temporary, and we thank the shipping and delivery personnel who are working hard for all of us during this global crisis.

Please Note: We have resumed our normal 30-Day Shipping Guarantee. We will provide updates as the situation changes.

Call Center

Our call center hours of operation are 6:00 am – 9:00 pm Central Time on Monday to Friday, and 7:00 am – 7:00 pm Central Time on Saturday and Sunday.

If you are experiencing increased hold times or are calling outside of these hours, please leave us a message or send us an email and we will get back to you as soon as we can. Due to increased demand on telephone networks worldwide, you may experience some intermittent connection problems. If this happens our agents will call you back.

Our Commitment

If you have any questions about any changes in our service please do not hesitate to contact us. Our staff are working tirelessly to ensure the timely fulfillment and delivery of all orders. The health and safety of our customers and staff is our highest priority and we remain committed to providing service at the highest level.

We appreciate your business and thank you for your continued support.


Management and Staff
Medix Pharmacy

Astagraf XL
(Tacrolimus ER)

Prescription Settings Edit

Brand Name Choices

Astagraf XL 0.5mg
Astagraf XL 0.5mg Extended Release Capsules

Marketed as Advagraf in Canada

Tacrolimus ER

Manufactured by Astellas Pharma

Product of Canada

Dispensed by an approved Canadian pharmacy partner

Prescription Required

Astagraf XL 0.5mg
Astagraf XL 0.5mg Extended Release Capsules

Marketed as Advagraf Prolonged Release in United Kingdom

Tacrolimus ER

Manufactured by Astellas Pharma

Product of United Kingdom

Dispensed by a licensed pharmacy in the United Kingdom

Prescription Required

Parallel Import

Astagraf XL 1mg
Astagraf XL 1mg Extended Release Capsules

Marketed as Advagraf in Canada

Tacrolimus ER

Manufactured by Astellas Pharma

Product of Canada

Dispensed by an approved Canadian pharmacy partner

Prescription Required

Advagraf 1mg
Advagraf 1mg Extended Release Capsules

Marketed as Advagraf Prolonged Release in United Kingdom

Tacrolimus ER

Manufactured by Astellas Pharma

Product of United Kingdom

Dispensed by a licensed pharmacy in the United Kingdom

Prescription Required

Parallel Import

Astagraf XL 3mg
Astagraf XL 3mg Extended Release Capsules

Marketed as Advagraf in Canada

Tacrolimus ER

Manufactured by Astellas Pharma

Product of Canada

Dispensed by an approved Canadian pharmacy partner

Prescription Required

Astagraf XL 3mg
Astagraf XL 3mg Extended Release Capsules

Marketed as Advagraf Prolonged Release in United Kingdom

Tacrolimus ER

Manufactured by Astellas Pharma

Product of United Kingdom

Dispensed by a licensed pharmacy in the United Kingdom

Prescription Required

Parallel Import

Astagraf XL 5mg
Astagraf XL 5mg Extended Release Capsules

Marketed as Advagraf Prolonged Release in United Kingdom

Tacrolimus ER

Manufactured by Astellas Pharma

Product of United Kingdom

Dispensed by a licensed pharmacy in the United Kingdom

Prescription Required

Parallel Import

Astagraf XL 5mg
Astagraf XL 5mg Extended Release Capsules

Marketed as Advagraf in Canada

Tacrolimus ER

Manufactured by Astellas Pharma

Product of Canada

Dispensed by an approved Canadian pharmacy partner

Prescription Required

More Brand Name Choices

Generic Choices

No generic medication is available for Astagraf XL (Tacrolimus ER)

What Astagraf XL is and what it is used for

Advagraf contains the active substance tacrolimus. It is an immunosuppressant. Following your organ transplant (liver, kidney), your body’s immune system will try to reject the new organ. Advagraf is used to control your body’s immune response, enabling your body to accept the transplanted organ. You may also be given Advagraf for an ongoing rejection of your transplanted liver, kidney, heart or other organ when any previous treatment you were taking was unable to control this immune response after your transplantation. Advagraf is used in adults.

How to take Astagraf XL

Always take Advagraf exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure. This medicine should only be prescribed to you by a doctor with experience in the treatment of transplant patients. Make sure that you receive the same tacrolimus medicine every time you collect your prescription, unless your transplant specialist has agreed to change to a different tacrolimus medicine. This medicine should be taken once a day. If the appearance of this medicine is not the same as usual, or if dosage instructions have changed, speak to your doctor or pharmacist as soon as possible to make sure that you have the right medicine. The starting dose to prevent the rejection of your transplanted organ will be determined by your doctor calculated according to your body weight. Initial daily doses just after transplantation will generally be in the range of 0.10 – 0.30 mg per kg body weight per day depending on the transplanted organ. When treating rejection, these same doses may be used. Your dose depends on your general condition and on which other immunosuppressive medication you are taking. Following the initiation of your treatment with Advagraf, frequent blood tests will be taken by your doctor to define the correct dose. Afterwards regular blood tests by your doctor will be required to define the correct dose and to adjust the dose from time to time. Your doctor will usually reduce your Advagraf dose once your condition has stabilised. Your doctor will tell you exactly how many capsules to take. You will need to take Advagraf every day as long as you need immunosuppression to prevent rejection of your transplanted organ. You should keep in regular contact with your doctor. Advagraf is taken orally once daily in the morning. Take Advagraf on an empty stomach or 2 to 3 hours after a meal. Wait at least 1 hour until the next meal. Take the capsules immediately following removal from the blister. The capsules should be swallowed whole with a glass of water. Do not swallow the desiccant contained in the foil wrapper. If you take more Advagraf than you should If you have accidentally taken too much Advagraf, contact your doctor or nearest hospital emergency department immediately. If you forget to take Advagraf If you have forgotten to take your Advagraf capsules in the morning, take them as soon as possible on the same day. Do not take a double dose the next morning. If you stop taking Advagraf Stopping your treatment with Advagraf may increase the risk of rejection of your transplanted organ. Do not stop your treatment unless your doctor tells you to do so. If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

Possible side effects

Like all medicines, Advagraf can cause side effects, although not everybody gets them. Advagraf reduces your body’s defence mechanism (immune system), which will not be as good at fighting infections. Therefore, you may be more prone to infections while you are taking Advagraf. Severe effects may occur, including allergic and anaphylactic reactions. Benign and malignant tumours have been reported following Advagraf treatment. Cases of pure red cell aplasia (a very severe reduction in red blood cell counts), agranulocytosis (a severely lowered number of white blood cells) and haemolytic anaemia (decreased number of red blood cells due to abnormal breakdown) have been reported.

Very common side effects (may affect more than 1 in 10 people):
•Increased blood sugar, diabetes mellitus, increased potassium in the blood
•Difficulty in sleeping
•Trembling, headache
•Increased blood pressure
•Liver function tests abnormal
•Diarrhoea, nausea
•Kidney problems

Common side effects (may affect up to 1 in 10 people):
•Reduction in blood cell counts (platelets, red or white blood cells), increase in white blood cell counts, changes in red blood cell counts (seen in blood tests)
•Reduced magnesium, phosphate, potassium, calcium or sodium in the blood, fluid overload, increased uric acid or lipids in the blood, decreased appetite, increased acidity of the blood, other changes in the blood salts (seen in blood tests)
•Anxiety symptoms, confusion and disorientation, depression, mood changes, nightmare, hallucination, mental disorders
•Fits, disturbances in consciousness, tingling and numbness (sometimes painful) in the hands and feet, dizziness, impaired writing ability, nervous system disorders
•Blurred vision, increased sensitivity to light, eye disorders
•Ringing sound in your ears
•Reduced blood flow in the heart vessels, faster heartbeat
•Bleeding, partial or complete blocking of blood vessels, reduced blood pressure
•Shortness in breath, disorders of the respiratory tissues in the lung, collection of liquid around the lung, inflammation of the pharynx, cough, flu-like symptoms
•Stomach problems such as inflammation or ulcer causing abdominal pain or diarrhoea, bleeding in the stomach, inflammation or ulcer in the mouth, collection of fluid in the belly, vomiting, abdominal pain, indigestion, constipation, passing wind, bloating, loose stools
•Bile duct disorders, yellowing of the skin due to liver problems, liver tissue damage and inflammation of the liver
•Itching, rash, hair loss, acne, increased sweating
•Pain in joints, limbs, back and feet, muscle spasms
•Insufficient function of the kidneys, reduced production of urine, impaired or painful urination
•General weakness, fever, collection of fluid in your body, pain and discomfort, increase of the enzyme alkaline phosphatase in your blood, weight gain, feeling of temperature disturbed
•Insufficient function of your transplanted organ

Uncommon side effects (may affect up to 1 in 100 people):
•Changes in blood clotting, reduction in the number of all types of blood cells (seen in blood tests)
•Dehydration, inability to urinate
•Abnormal blood test results: reduced protein or sugar, increased phosphate, increase of the enzyme lactate dehydrogenase
•Coma, bleeding in the brain, stroke, paralysis, brain disorder, speech and language abnormalities, memory problems
•Clouding of the eye lens, impaired hearing
•Irregular heartbeat, stop of heartbeat, reduced performance of your heart, disorder of the heart muscle, enlargement of the heart muscle, stronger heartbeat, abnormal ECG, heart rate and pulse abnormal
•Blood clot in a vein of a limb, shock
•Difficulties in breathing, respiratory tract disorders, asthma
•Obstruction of the gut, increased blood level of the enzyme amylase, reflux of stomach content in your throat, delayed emptying of the stomach
•Inflammation of the skin, burning sensation in the sunlight
•Joint disorders
•Painful menstruation and abnormal menstrual bleeding
•Multiple organ failure, flu-like illness, increased sensitivity to heat and cold, feeling of pressure on your chest, jittery or abnormal feeling, weight loss

Rare side effects (may affect up to 1 in 1,000 people):
•Small bleedings in your skin due to blood clots
•Increased muscle stiffness
•Blindness, deafness
•Collection of fluid around the heart
•Acute breathlessness
•Cyst formation in your pancreas
•Problems with blood flow in the liver
•Serious illness with blistering of skin, mouth, eyes and genitals; increased hairiness
•Thirst, fall, feeling of tightness in your chest, decreased mobility, ulcer

Very rare side effects (may affect up to 1 in 10,000 people):
•Muscular weakness
•Abnormal heart scan
•Liver failure
•Painful urination with blood in the urine
•Increase of fat tissue

Reporting of side effects If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.

How to Store Astagraf XL

Keep out of the sight and reach of children. Do not use Advagraf after the expiry date which is stated on the carton after “Exp”. The expiry date refers to the last day of that month. Use all the prolonged-release hard capsules within 1 year of opening the aluminium wrapping. Store in the original package in order to protect from moisture. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

Fast Shipping

2 to 3 weeks on average

The average shipping time is 2 weeks in North America and 4 weeks internationally. We offer free shipping on all orders shipped to North America. Shipping is a flat rate of $20.00 for all other countries.

Price Match Guarantee

If you have been prescribed medication by your doctor and cannot afford the high price at your local pharmacy, Medix Pharmacy is the solution for you. All orders are backed with a price match and satisfaction guarantee.

Your Trusted Pharmacy Referral Service

Medix Pharmacy is an international pharmacy referral service. With a network of licensed pharmacy partners in Canada, United Kingdom, Australia, and New Zealand, we are able to help you lower the costs of your medications.

Our pharmacy partners are all thoroughly vetted and qualified to ensure that the medication you receive is cost effective, safe and effective. Because we only work with licensed pharmacies, you can rest assured that your medication is safe, effective, and genuine.

  • Free standard delivery to your door, to any international address
  • Option to add Tracked Deliveries
  • Handy reminders to re-order so you do not run out
  • Professional & Knowledgeable Customer Services Team
  • Save time, with no need for repeated trips to your physician or local drugstore

With a dedicated customer service team, free standard shipping, and a record of providing significant saving for our customers, we believe that you do not need to compromise quality or safety in your search for value.

If you are unable to find your prescribed medicine on our website, please fill out the form below and we will confirm pricing and availability within 1 business day. You may also call us at 1-866-500-6633 and one of our patient care representatives will be happy to assist you.