Brand Name Choices
What Aygestin is and what it is used for
Utovlan is one of a group of medicines called ‘Progestogens’. Progestogens are similar to the natural female hormone progesterone. Utovlan contains the progestogen called norethisterone as the active ingredient. Utovlan has many uses. You can take Utovlan to treat or manage:
•Irregular periods or periods that are more frequent than normal
•Premenstrual tension (PMT)
•Endometriosis (where tissue from your womb is found outside your womb)
•Breast cancer. Your doctor may also prescribe Utovlan if you want to delay your next period
How to take Aygestin
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. The recommended dose will depend on the condition you are being treated for. This information can also be found on the label on the box the tablets come in. The following information will help you see what the usual dose is for a particular problem. Taking Utovlan for heavy bleeding and other period problems
•You will usually take 1 tablet 3 times a day (15 mg) for 10 days. A few days after you stop taking the tablets you will usually have bleeding like a period. To stop your periods causing problems again, your doctor may tell you to take Utovlan for a few days after your next two periods. You will probably take 1 tablet twice a day (10 mg) for 8 days. You will need to start taking these tablets 19 days after your last period began. Taking Utovlan for premenstrual tension
•You will usually take one 5 mg tablet a day for 10 days, starting 16 days after your last period began. Taking Utovlan for endometriosis
•You will usually take 1 tablet 3 times (15 mg) a day for at least 6 months. If you have any irregular bleeding or spotting, your doctor may increase the dose to 4 or 5 tablets (20-25 mg) a day until this bleeding stops. Taking Utovlan for breast cancer
•You will usually take 8 tablets (40 mg) a day. Your doctor may increase this to 12 tablets (60 mg). Taking Utovlan to delay your periods
•You will usually take 1 tablet 3 times (15 mg) a day. You need to start taking the tablets 3 days before your period is due to start. Your period will usually start within 3 days of finishing the tablets. If you do not have a period after you finish a course of Utovlan, check with your doctor in case you are pregnant. If you take more Utovlan than you should If you take too many tablets, contact your doctor straight away. If you forget to take Utovlan Take the tablet as soon as you remember, and carry on taking the tablets at the normal times. Do not take a double dose to make up for a forgotten dose. If you have any further questions on the use of this medicine, ask your doctor or pharmacist.
Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them. Reasons for stopping Utovlan treatment immediately
Very rarely, Utovlan may cause a severe allergic reaction which can be life-threatening in some cases. You can get some or all of the following symptoms:
• difficulty breathing
• feeling faint
• swelling of the face or tongue
• swelling of the hands and feet
• intense itchy skin rash. If you think you are reacting badly to the medicine, get emergency medical help immediately. The following symptoms could be warning signs of thrombosis (a blood clot) which will need urgent treatment: Symptoms of a blood clot in the lungs:
•Sudden, severe, sharp pain in your chest
•Coughing up blood
•You suddenly become short of breath
•Your heart beats more rapidly Symptoms of a blood clot in the brain (‘a stroke’):
•You have an unusually severe or long headache
•Your sight is affected in any way
•You find it difficult to speak
•You collapse or faint
•Any part of your body feels weak or numb Symptoms of a deep-vein thrombosis (DVT):
•You have severe pain, tenderness or swelling in your calf, ankle or foot
•You have purple discolouration of the skin of the leg or the skin becomes red and warm to touch If you get any of these symptoms, you should stop taking the tablets and see your doctor immediately. Reasons for seeking medical advice during treatment It is important to see your doctor straightaway if you get:
•Yellowing of the skin or whites of the eyes (jaundice)
•Migraine headache for the very first time Your doctor may also decide to stop treatment if your blood pressure gets too high.
Other side effects You can also get the following side effects with medicines like Utovlan: Effects on the reproductive system and breasts: bleeding and spotting between periods, lack of periods (amenorrhoea), unexpected or unusual vaginal bleeding, changes in discharge from the cervix, cervical erosions (this may be seen when you have a smear test), cycles where you don’t ovulate (anovulation), breast pain and tenderness, a milky discharge from the breast when not pregnant or breastfeeding (galactorrhoea). Effects on the nervous system: headache, depression, dizziness, fatigue, difficulty sleeping, confusion, nervousness, a feeling of intense happiness (euphoria), feeling sleepy, loss of concentration, vision problems. Effects on the stomach and intestines: feeling or being sick, constipation, diarrhoea, dry mouth. Effects on the liver: disturbed liver function, yellowing of the skin or whites of the eyes. Cysts and tumours: a liver disorder, such as a benign liver tumour. These mostly do not cause any symptoms but can sometimes be felt. Benign liver tumours can sometimes cause severe abdominal pain. Effects on your metabolism: altered fat levels in the blood, alteration of blood sugar levels, increased levels of insulin between meals and existing diabetes getting worse, decreased tolerance to some sugars like glucose, adrenergic-like effects (e.g. fine hand tremors, sweating, cramps in the calves at night), effects on the adrenal glands (e.g. Cushingoid syndrome), cloudy vision, sugar in your urine. Effects on your heart and circulation: blood clots, including clots in the lung, and swelling in the veins due to blood clots, stroke, heart attacks, congestive heart failure, increased blood pressure, feeling your heartbeat, clots in the blood vessels of the retina (this causes visual problems), heart beating faster (tachycardia). Effects on your skin and hair: acne, increase in body or facial hair, hair loss, itching, rash, hives. Miscellaneous: fluid retention and swelling of hands and ankles, bloating, weight gain, raised temperature, change in appetite, changes in sex drive, fatigue, increase in calcium (seen in blood tests). If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via Yellow Card Scheme Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety
How to Store Aygestin
Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the carton and blister strip after EXP. The expiry date refers to the last day of that month. Store below 25°C. Store in the original package to protect from light and moisture. Do not throw away any medicines via waste water or household waste. Ask your pharmacist how to throw away medicine you no longer use. These measures will help protect the environment.
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