What Entresto is and what it is used for
Entresto is a medicine known as an angiotensin receptor neprilysin inhibitor. It dissociates into two active substances, sacubitril and valsartan. Entresto is used to treat a type of long-term heart failure in adults. This type of heart failure occurs when the heart is weak and cannot pump enough blood to the lungs and the rest of the body. The most common symptoms of heart failure are breathlessness, fatigue, tiredness and ankle swelling.
How to take Entresto
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. You will usually start by taking 24 mg/26 mg or 49 mg/51 mg twice a day (one tablet in the morning and one tablet in the evening). Your doctor will decide your exact starting dose based on which medicines you have been taking previously. Your doctor will then adjust the dose depending on how you respond to the treatment until the best dose for you is found. The usual recommended target dose is 97 mg/103 mg twice a day (one tablet in the morning and one tablet in the evening). Patients taking Entresto can develop low blood pressure (dizziness, light-headedness), a high level of potassium in the blood (which would be detected when your doctor performed a blood test) or decreased kidney function. If this happens, your doctor may reduce the dose of any other medicine you are taking, temporarily reduce your Entresto dose, or stop your Entresto treatment completely. Swallow the tablets with a glass of water. You can take Entresto with or without food. If you take more Entresto than you should If you have accidentally taken too many Entresto tablets, or if someone else has taken your tablets, contact your doctor immediately. If you experience severe dizziness and/or fainting, tell your doctor as quickly as possible and lie down. If you forget to take Entresto It is advisable to take your medicine at the same time each day. However, if you forget to take a dose, you should simply take the next one at the scheduled time. Do not take a double dose to make up for a forgotten tablet. If you stop taking Entresto Stopping your treatment with Entresto may cause your condition to get worse. Do not stop taking your medicine unless your doctor tells you to. If you have any further questions on the use of this medicine, ask your doctor or pharmacist
Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Some side effects may be serious.
• Stop taking Entresto and seek immediate medical attention if you notice any swelling of the face, lips, tongue and/or throat, which may cause difficulties in breathing or swallowing. These may be signs of angioedema (an uncommon side effect which may affect up to 1 in 100 people). Other possible side effects: If any of the side effects listed below becomes severe, tell your doctor or pharmacist.
Very common (may affect more than 1 in 10 people):
• low blood pressure (dizziness, light-headedness)
• high level of potassium in the blood (shown in a blood test)
• decreased renal function (renal impairment)
Common (may affect up to 1 in 10 people):
• low level of red blood cells (shown in a blood test)
• (acute) renal failure (severe kidney disorder)
• low level of potassium in the blood (shown in a blood test)
• feeling sick (nausea)
• low blood pressure (dizziness, light-headedness) when switching from sitting or lying to standing position
• gastritis (stomach pain, nausea)
• spinning sensation
• low level of sugar in the blood (shown in a blood test)
Uncommon (may affect up to 1 in 100 people):
• allergic reaction with rash and itching
• dizziness when switching from sitting to standing position
Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly (see details below). By reporting side effects you can help provide more information on the safety of this medicine. Ireland: HPRA Pharmacovigilance Earlsfort Terrace IRL
•Dublin 2 Tel: +353 1 6764971 Fax: +353 1 6762517 Website: www.hpra.ie e-mail: [email protected] Malta: ADR Reporting Website: www.medicinesauthority.gov.mt/adrportal 5 United Kingdom: Yellow Card Scheme Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store
How to Store Entresto
Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the carton and blister after EXP. The expiry date refers to the last day of that month. This medicine does not require any special temperature storage conditions. Store in the original package in order to protect from moisture. Do not use any Entresto pack that is damaged or shows signs of tampering. Do not throw away any medicines via wastewater. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.
2 to 3 weeks on average
The average shipping time is 2 weeks in North America and 4 weeks internationally. We offer free shipping on all orders shipped to North America. Shipping is a flat rate of $20.00 for all other countries.
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