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What Inspra is and what it is used for
Inspra belongs to a group of medicines known as selective aldosterone blocking agents. These blocking agents inhibit the action of aldosterone, a substance produced within the body, which controls your blood pressure and heart function. High levels of aldosterone can cause changes in your body that lead to heart failure. Inspra is used to treat your heart failure to prevent worsening and reduce hospitalisations if you have: 1. had a recent heart attack, in combination with other drugs that are used to treat your heart failure, or 2. have persistent, mild symptoms despite the treatment you have been receiving so far.
How to take Inspra
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure. Inspra tablets may be taken together with food or on an empty stomach. Swallow the tablets whole with plenty of water. Inspra is usually administered together with other medication for heart failure e.g. beta blockers. The usual starting dose is one 25 mg tablet once daily, increasing after about 4 weeks to 50 mg once daily (either as one 50 mg tablet or two 25 mg tablets). The maximum dose regimen is 50 mg daily. Blood potassium levels should be measured before starting Inspra therapy, within the first week and at one month after the start of treatment or after a change in dose. The dose may be adjusted by your doctor, depending on the potassium levels in your blood. If you have mild kidney disease, you should start on one 25 mg tablet every day. And if you have moderate kidney disease, you should start on one 25 mg tablet every other day. These doses may be adjusted if your doctor recommends and according to your blood potassium levels. In patients with severe kidney disease, Inspra is not recommended. In patients with mild-to-moderate liver disease no adjustment of the starting dose is required. If you have liver or kidney problems, you may need more frequent testing of your blood potassium levels (see also “Do not take Inspra”). For the elderly: no adjustment of the starting dose is required. For children and adolescents: Inspra is not recommended. If you take more Inspra than you should If you take more Inspra than you should, tell your doctor or pharmacist immediately. If you have taken too much of your medicine, the most likely symptoms will be low blood pressure (expressed as a light feeling in your head, dizziness, blurred vision, weakness, acute loss of consciousness) or hyperkalemia, high levels of potassium in the blood (expressed by muscle cramps, diarrhoea, nausea, dizziness or headache). If you forget to take Inspra If it is almost time for your next tablet, skip the tablet you missed and take your next tablet when it is due. Otherwise take the tablet as soon as you remember, providing there is more than 12 hours to when you are due to take your next tablet. Then go back to taking your medicine as you would normally. Do not take a double dose to make up for the forgotten tablet. If you stop taking Inspra It is important to keep taking Inspra as prescribed unless your doctor tells you to stop your treatment. If you have any further questions on the use of this medicine ask your doctor or pharmacist.
Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them. If you experience any of the following: You should seek immediate medical attention
• swollen face, tongue or throat
• difficulty swallowing
• hives and difficulties breathing These are the symptoms of angioneurotic oedema, an uncommon (affecting up to 1 in 100 people) side effect. Other reported side effects include:
Common side-effects (may affect up to 1 in 10 people):
• elevated potassium level in your blood (symptoms include muscle cramps, diarrhoea, nausea, dizziness or headache)
• elevated quantity of cholesterol in your blood
• insomnia (difficulty sleeping)
• heart complaints e.g., irregular heartbeat and heart failure
• low blood pressure
• abnormal functioning of your kidney
• back pain
• feeling weak
• muscle spasm
• increased urea level in the blood
• increased creatinine blood levels which may indicate kidney problems
Uncommon side-effects (may affect up to 1 in 100 people):
• eosinophilia (increase in certain white blood cells)
• low sodium blood levels
• elevated quantity of triglycerides (fats) in your blood
• fast heart beat
• inflammation of the gall bladder
• decreased blood pressure that can cause dizziness upon standing
• thrombosis (blood clot) in the leg
• sore throat
• underactive thyroid
• increase in blood glucose
• reduced sense of touch
• increased sweating
• musculoskeletal pain
• feeling generally unwell
• kidney inflammation
• enlargement of breasts in men
• changes in some blood test results
Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly (see details below). By reporting side effects you can help provide more information on the safety of this medicine. United Kingdom Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store Ireland HPRA Pharmacovigilance, Earlsfort Terrace, IRL
•Dublin 2; Tel: +353 1 6764971; Fax: +353 1 6762517. Website: www.hpra.ie; E-mail: [email protected]
How to Store Inspra
Keep this medicine out of the sight and reach of children. This medicinal product does not require any special storage conditions. Do not use this medicine after the expiry date which is stated on the pack and blister after EXP. The expiry date refers to the last day of that month. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment
2 to 3 weeks on average
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