Brand Name Choices
What Lialda is and what it is used for
Pharmacotherapeutic group: Aminosalicylic acid and similar agents. Mezavant gastro-resistant, prolonged release tablets contain the active substance mesalazine, which is an anti-inflammatory drug for the treatment of ulcerative colitis. Ulcerative colitis is a disease of the colon (large bowel) and rectum (back passage), where the lining of the gut becomes red and swollen (inflamed) resulting in symptoms of frequent and bloody stools together with stomach cramps. When given for an acute episode of ulcerative colitis, Mezavant acts through the entire colon and rectum to treat the inflammation and reduce symptoms. The tablets can also be taken to help prevent reccurrence of ulcerative colitis.
How to take Lialda
Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure. The recommended dose for adults is 2.4g to 4.8g (two to four tablets) taken once a day for an acute episode of ulcerative colitis. If you are taking the highest daily dose of 4.8g/day, you should be evaluated after 8 weeks treatment. Once your symptoms have cleared and to help prevent reoccurrence of another episode, your doctor should direct you to take 2.4g (two tablets) once a day. Remember to take your tablets at the same time each day with food. The tablets should be swallowed whole and must not be crushed or chewed. Whilst taking this medicine ensure you drink fluids to remain well hydrated especially after severe or prolonged episodes of vomiting and/or diarrhoea, high fever or heavy sweating. Mezavant is not recommended to be given to children under 18 years of age due to lack of data on safety and efficacy. If you take more Mezavant than you should If you take too much Mezavant you may have one or more of the following symptoms: tinnitus (ringing in ears), dizziness, headache, confusion, drowsiness, shortness of breath, excess loss of water (associated with sweating, diarrhoea and vomiting), low blood sugar (which can cause lightheadedness), rapid breathing, changes in the blood chemistry and increased body temperature. If you do take too many tablets, contact your doctor, pharmacist or hospital casualty department straight away. Take your tablet pack with you. If you forget to take Mezavant It is important to take your Mezavant tablets every day, even when you don’t have any symptoms of ulcerative colitis. Always finish the prescribed course. If you forget to take your tablets then take them as usual the next day. Do not take a double dose to make up for a forgotten tablet. If you have any further questions on the use of this medicine, ask your doctor or pharmacist
Possible side effects
Tell your doctor immediately
If you experience symptoms such as cramping, severe stomach pain, bloody and excessive
stools (diarrhoea), fever, headache or rash. These symptoms could be a sign of Acute
Intolerance Syndrome which can happen during an acute episode of ulcerative colitis. This is a
serious condition which occurs rarely, but means your treatment would have to be stopped
If you develop unexplained bruising (without injury), rash, anaemia (feeling tired, weak and
looking pale, especially on lips, nails and inside of eyelids), fever (high temperature), sore
throat or unusual bleeding (e.g. nose bleeds)
If you develop allergic swelling of tongue, lips and around eyes
If you develop increased pressure in brain causing headache which may originate behind your
eyes and worsen with eye movements, with blurred or dimmed vision, double vision, seeing
light flashes, difficulty seeing to the side, and brief or permanent vision loss. These may be
associated with dizziness, nausea, vomiting, ringing in ears
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Common side effects, occurring in less than 1 in 10 patients are: headache; changes in blood pressure, flatulence (passing wind); nausea (feeling sick); bloated or painful stomach; inflammation which causes abdominal pain or diarrhoea; diarrhoea; indigestion; vomiting (being sick); abnormal liver function test; itching; rash, joint pain; back pain; weakness, fatigue (feeling extremely tired); fever (high temperature).
Uncommon side effects, seen in less than 1 in 100 patients are: a reduction in blood platelets which increases the risk of bleeding and bruising; dizziness; feeling sleepy or tired; trembling or shaking; ear pain; racing heartbeat; throat pain; an inflamed pancreas (associated with pain in upper abdomen and back and feeling sick); rectal polyp (a non-cancerous growth in the back passage causing symptoms such as constipation and bleeding); acne; hair loss; muscle pain; hives; swollen face.
Rare side effects, seen in less than 1 in 1000 patients are: kidney failure; severe reduction in the number of white blood cells that makes infection more likely.
The following side effects have been reported but it is not known exactly how often they occur: Severe reduction in blood cells which can cause weakness or bruising; low blood cell counts; allergic reaction (hypersensitivity); serious allergic reaction which causes difficulty in breathing or dizziness; serious illness with blistering of the skin, mouth, eyes and genitals; allergic reaction which causes skin rash, fever and inflammation of internal organs; neuropathy (abnormal or damaged nerves giving a sensation of numbness and tingling); inflammation of the heart and lining around the heart; inflammation of the lung; difficulty in breathing or wheezing; gall stones; hepatitis (inflammation of the liver giving rise to flu-like symptoms and jaundice); allergic swelling of tongue, lips and around eyes; skin redness; skin rash typically on face, skin sensitivity to sunlight along with joint pain, arthritis, fatigue and overall feeling sickness; kidney problems (such as inflammation and scarring of the kidney). If you get any side effects, talk to your doctor. This includes any possible side effects not listed in this leaflet.
Reporting of side effects If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the national reporting system (see below). By reporting side effects you can help provide more information on the safety of this medicine. United Kingdom Yellow Card Scheme Website: https://www.mhra.gov.uk/yellowcard Ireland HPRA Pharmacovigilance Earlsfort Terrace IRL
•Dublin 2 Tel: +353 1 6764971 Fax: +353 1 6762517 Website: www.hpra.ie e-mail: [email protected] Malta ADR Reporting Website: www.medicinesauthority.gov.mt/adrportal
How to Store Lialda
Keep this medicine out of the sight and reach of children
• Store below 25°C
• Store in the original package in order to protect from moisture
• Do not use this medicine after the expiry date which is stated on the box after “EXP”. The expiry date refers to the last day of the month
• Do not throw away any medicines via waste water or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help to protect the environment.
2 to 3 weeks on average
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