Proglycem
(Diazoxide)

Prescription Settings Edit

Brand Name Choices

Proglycem 100mg
Proglycem 100mg

Diazoxide

Manufactured by Merck Canada Inc

Product of Canada

Dispensed by an approved Canadian pharmacy partner

Prescription Required

Proglycem 50mg
Proglycem 50mg

Marketed as Eudemine in United Kingdom

Diazoxide

Manufactured by Focus Pharmaceuticals Ltd

Product of United Kingdom

Dispensed by a licensed pharmacy in the United Kingdom

Currently Unavailable.

Generic Choices

No generic medication is available for Proglycem (Diazoxide)

What Proglycem is and what it is used for

Eudemine belongs to a group of medicines called thiazides. These work by increasing levels of sugar in the blood. Eudemine is used to treat a condition called ‘intractable hypoglycaemia’. This is when the sugar level in your blood has been very low for a long time. A low sugar level in the blood is caused by an increase in the amount of the hormone insulin, being produced by the pancreas. It is important to take this medicine as very low blood sugar can result in unusual behaviour, (such as aggression), sweating, a fast pulse and can lead to a coma, which may occur quite suddenly.

How to take Proglycem

Always take Eudemine exactly as your doctor has told you. Important: Your doctor will choose the dose that is right for you. Your dose will be shown clearly on the label that your pharmacist puts on your medicine. If it does not, or you are not sure, ask your doctor or pharmacist. How much to take Adults and children
• The usual daily starting dose is 5 mg for every kilogram of body weight. The total amount is divided into 2 or 3 doses that are taken throughout the day
• Your doctor may increase your dose until it is right for you
• The usual daily maintenance dose is between 3 and 8 mg for every kilogram of body weight. This total is then divided into two or three doses taken throughout the day. People with Kidney problems If you have kidney problems your doctor may choose a lower dose for you. Children with leucine-sensitive hypoglycaemia For children with a certain type of hypoglycaemia known as ‘leucine-sensitive hypoglycaemia’, the usual dose is between 15 and 20 mg per kilogram per day. Adults with tumours of the pancreas If you are an adult with tumours of the pancreas which produce large amounts of the hormone insulin you may require high doses of up to 1000 mg per day. Medical check-ups While you are taking this medicine, your doctor may ask you to have checkups. These are to make sure that your medicine is working properly and that the dose you are taking is right for you.
• Your doctor will check your blood sugar levels regularly in the first few days of treatment to see how the drug is working
• Your doctor will regularly check your blood pressure
• Eudemine causes the body to retain water so you may need to take another medicine called a diuretic to help your body get rid of this water. If you have to take a diurectic, your doctor may reduce your dose of Eudemine P atient Inform atio n Leaflet E u demine 5 0 m g Ta blets Diazo xide
• Your doctor may prescribe a potassium supplement for you to stop your potassium levels going too low
• Your doctor may check the level of uric acid in your blood if you have a history of high uric acid levels or gout
• If you take Eudemine for a long time your doctor will monitor the levels of your blood cells
• In children the doctor will check the rate they are growing and developing. If you take more Eudemine than you should If you accidentally take too much, immediately go to the nearest hospital casualty department or your doctor. Too much Eudemine can cause very high levels of sugar in your blood. This will be treated with other drugs to bring your blood sugar back to normal. Too much Eudemine may also cause your blood pressure to fall and again, you may be given other medicines to bring this back to normal. If you forget to take Eudemine Do not take a double dose to make up for a missed dose. Simply take the next dose as planned. If you stop taking Eudemine Do not stop taking Eudemine without first talking to your doctor. If you have any further questions about the use of this medicine, ask your doctor or pharmacist.

Possible side effects

Like all medicines Eudemine can cause side effects, although not everybody gets them. Seek immediate medical help if you feel faint or dizzy, especially when you stand up. Effects on your heart and circulation
• Fast or irregular heart beat (palpitations)
• Chest pains
• Collapse
• Anaemia (which may make you feel tired)
• Reduced blood platelets (which increases the chances of bleeding or bruising)
• Changes to white blood cells (which may cause a sore throat and fever). Effects on the nervous system
• Coma
• Symptoms similar to those seen in Parkinson’s disease, such as shaking of the hands, difficulty moving and rolling of the eyes. Your doctor may treat these with an anti-Parkinson’s drug
• Headache Effects on liver or kidneys
• Weight gain
• Feeling bloated and swollen
• Changes in the way the liver and kidney’s work, seen from blood or urine test results. Effects on stomach and bowels
• Feeling and being sick, especially during the first 2-3 weeks of taking Eudemine. Your doctor may give you another medicine to stop this.
• Stomach pain
• Loss of appetite
• Diarrhoea
• Constipation. Effects on the eyes and skin
• Sensitivity reactions such as rash or fever
• Blurred vision
• Cataracts which are temporary
• Increased growth of body hair. Other effects
• Breathlessness
• Muscle pain
• High levels of uric acid in the blood (which may cause joint pain)
• Changes to voice and abnormal facial features in children
• Hyperglycaemia (high sugar levels in the blood) which may cause you to pass large amounts of urine and/or make you thirsty.

Reporting of side effects If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via Yellow Card Scheme on the MHRA website (www.mhra.gov.uk/yellowcard). By reporting side effects you can help provide more information on the safety of this medicine.

How to Store Proglycem

Keep this medicine out of the sight and reach of children. Do not use Eudemine after the expiry date on the label. The expiry date refers to the last day of that month. Medicines should not be disposed of via wastewater or household waste. Return any medicine you no longer need to your pharmacist.

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