COVID-19 SERVICE UPDATE - WE CONTINUE TO OFFER GREAT SAVINGS DURING THE PANDEMIC!

Shipping Update - May 1 2022

Shipping times are now closer to normal. However, due to the latest outbreak of the highly contagious Omicron strain, some delays in shipping times may still occasionally occur. We will provide updates as the situation changes.

Our normal shipping time averages 1 - 2 weeks. Shipments may sometimes take an additional 2 weeks to arrive, depending on the source country of your order.

Please note that these times are averages and individual shipping times will vary. We recommend that you place your order at least 2 - 4 weeks or more ahead of your normal reorder time to avoid running out of your medication.

We offer a shipping guarantee when you place an order with us. If your order does not arrive within 6 weeks from the date it was shipped, we will re-ship your order to you at no additional cost.

Call Center - New Hours effective April 1, 2022

Our call center hours of operation are now 6:00 am - 9:00 pm Central Time on Monday to Friday, and 7:00 am - 7:00 pm Central Time on Saturday and Sunday.

If you are experiencing increased hold times or are calling outside of these hours, please leave us a message or send us an email and we will get back to you as soon as we can. Due to increased demand on telephone networks worldwide, you may experience some intermittent connection problems. If this happens our agents will call you back.

Our Commitment

If you have any questions about any changes in our service please do not hesitate to contact us. Our staff are working tirelessly to ensure the timely fulfillment and delivery of all orders. The health and safety of our customers and staff is our highest priority and we remain committed to providing service at the highest level.

We appreciate your business and thank you for your continued support.

Management and Staff
Medix Pharmacy

Sinemet CR
(Levodopa/Carbidopa CR)

Prescription Settings Edit

Brand Name Choices

Sinemet CR 100/25mg
Sinemet CR 100/25mg Extended Release Tablets

Marketed as Half Sinemet CR in United Kingdom

Levodopa/Carbidopa CR

Manufactured by Merck Sharp & Dohme Ltd

Product of United Kingdom

Dispensed by a licensed pharmacy in the United Kingdom

Prescription Required

Parallel Import

Sinemet CR 100/25mg
Sinemet CR 100/25mg Extended Release Tablets

Levodopa/Carbidopa CR

Manufactured by Merck Canada Inc

Product of Canada

Dispensed by an approved Canadian pharmacy partner

Prescription Required

Sinemet CR 200/50mg
Sinemet CR 200/50mg Extended Release Tablets

Levodopa/Carbidopa CR

Manufactured by Merck

Product of New Zealand

Dispensed by an international pharmacy partner

Prescription Required

Sinemet CR 200/50mg
Sinemet CR 200/50mg Extended Release Tablets

Levodopa/Carbidopa CR

Manufactured by Merck Sharp & Dohme Ltd

Product of United Kingdom

Dispensed by a licensed pharmacy in the United Kingdom

Currently Unavailable.
More Brand Name Choices

Generic Choices

Levodopa/Carbidopa CR 100/25mg
Levodopa/Carbidopa CR 100/25mg Extended Release Tablets

Generic Equivalent of Sinemet CR 100/25mg

Manufactured by Various UK Generic Manufacturers (MHRA Approved)

Product of United Kingdom

Dispensed by a licensed pharmacy in the United Kingdom

Prescription Required

Levodopa/Carbidopa CR 100/25mg
Levodopa/Carbidopa CR 100/25mg Extended Release Tablets

Marketed as AA-Levocarb CR in Canada

Generic Equivalent of Sinemet CR 100/25mg

Manufactured by AA Pharma

Product of Canada

Dispensed by an approved Canadian pharmacy partner

Prescription Required

More Generic Choices

What Sinemet CR is and what it is used for

Sinemet CR improves the signs of Parkinson’s disease. Parkinson's disease is a longterm illness where:
• you become slow and unsteady
• your muscles feel stiff
• you may develop shaking or trembling (called ‘tremor’). If not treated, Parkinson's disease can make it hard for you to continue your normal daily activities. Sinemet CR contains two different medicines called: levodopa and carbidopa.
• levodopa turns into a material called ‘dopamine’ in your brain. The dopamine helps to improve the signs of your Parkinson’s disease.
• carbidopa belongs to a group of medicines called ‘aromatic amino acid decarboxylase inhibitors’. It helps levodopa work more effectively by slowing the speed at which levodopa is broken down in your body

How to take Sinemet CR

Always take Sinemet CR exactly as your doctor has told you. You should check with your doctor or pharmacist if you are not sure. Taking this medicine
• Take this medicine by mouth. You must swallow your tablets whole. Do not break, crush or chew the tablets. 3
• Although your medicine can have an effect after one day, it may take up to seven days to work.
• Take them at regular time intervals according to your doctor's instructions.
• Do not change the times at which you take your tablets or take any other medicines for Parkinson's disease without first consulting your doctor. You should not take Sinemet CR or Half Sinemet CR tablets at intervals of less than 4 hours apart.
• Try to avoid taking your tablets with a heavy meal. If you have not had levodopa before The usual starting dose for Sinemet CR is one tablet twice a day. If you have had levodopa before
• your doctor will ask you to stop taking your medicine for Parkinson’s disease for 8 hours before you start taking Sinemet CR. The usual starting dose for Sinemet CR is one tablet twice a day. Your doctor may ask you to take Half Sinemet CR to help in determining the correct dose. A combination of more than one Sinemet or Sinemet CR product may be prescribed by your doctor. If you have been given different Sinemet or Sinemet CR tablets to take make sure that you are taking the correct one at the right time. Remember: Half Sinemet CR is a lower dose tablet than Sinemet CR. Children under 18 years of age Sinemet CR is not suitable for children under the age of 18 years. If you take more Sinemet CR than you should If you take too many tablets see your doctor immediately. If you forget to take Sinemet CR Do not take a double dose to make up for a forgotten dose. If you stop taking Sinemet CR Do not stop taking Sinemet CR or change your dose without talking to your doctor first. When you stop taking Sinemet CR the following can occur: stiff muscles, high temperature (fever) and mental changes. If you have any further questions on the use of this product, ask your doctor or pharmacist.

Possible side effects

Like all medicines, Sinemet CR can cause side effects, although not everybody gets them. Stop taking Sinemet CR and see your doctor straight away, if you notice any of the following side effects:
• allergic reaction, the signs may include hives (nettle rash), itching, rash, swelling of your face, lips, tongue or throat. This may cause difficulty in breathing or swallowing
• chest pain 4
• uneven (irregular) heart beat or palpitations
• dizziness on standing-up quickly
• bleeding from your gut which may be seen as blood in your faeces or darkened faeces (gastro-intestinal bleeding)
• blood problems, the signs may include pale skin (pallor), tiredness, fever, sore throat or mild bruising and prolonged bleeding after injury
• stiff muscles, high fever
• mental changes including delusions, hallucinations and depression
• fits (convulsions). The most common side effects are
• abnormal movements such as twitching or spasms (which may or may not be like your Parkinson's symptoms)
• nausea.

Other side effects include
• fainting, anorexia, high blood pressure
• inflammation of the veins, being sick (vomiting), diarrhoea, discoloration of urine, sweat or saliva
• on-off phenomenon, characteristic of some people with long-standing Parkinson’s disease. This is when you can have unpredictable changes from being mobile
•“on”
•to a sudden inability to move
•“off”. “Off” to “on” can occur just as suddenly
• dizziness; sleepiness (including excessive drowsiness or sudden sleep onset episodes), pins and needles
• dream abnormalities, confusion, feeling agitated, shortness of breath, hair loss. You may experience the following side effects:
• Craving for large doses of Sinemet CR in excess of that required to control motor symptoms, known as dopamine dysregulation syndrome. Some patients experience severe abnormal involuntary movements (dyskinesias), mood swings or other side effects after taking large doses of Sinemet CR.
• inability to resist the impulse to perform an action that could be harmful, which may include: o strong impulse to gamble excessively despite serious personal or family consequences o altered or increased sexual interest and behaviour of significant concern to you or to others, for example, an increased sexual drive o uncontrollable excessive shopping or spending o binge eating (eating large amounts of food in a short time period) or compulsive eating (eating more food than normal and more than is needed to satisfy your hunger) Tell your doctor if you experience any of these behaviours; he/she will discuss ways of managing or reducing the symptoms. Side effects that have been reported with medicines containing levodopa. These may be experienced when taking Sinemet CR. 5 Nervous system:
• loss of control over the voluntary movements of everyday life
• numbness, increased hand tremor, muscle twitching, muscle cramp, irregular movement of jaw muscles resulting in difficulty opening the mouth
• difficulty sleeping, feeling anxious or high, falling over and abnormal walking patterns
• headache Eyes:
• drooping eyelid and dilated pupil
• changes in vision, irregular movement of the eye Digestive system:
• indigestion, dry mouth, bitter taste
• swelling of the salivary glands, difficulty swallowing, grinding of the teeth
• hiccups, abdominal pain and distress, constipation, wind
• burning sensation of the tongue Sexual:
• persistent abnormal erection of the penis Urinary:
• difficulty passing urine or incontinence (inability to control urine flow) Skin:
• changed patches of pigmented skin, including, irritated or irregular moles, or moles in which you have noticed changes (melanoma) General:
• weight gain or loss, swelling in the limbs
• flushing, hot flushes, increased sweating
• feeling weak, faint or tired
• hoarseness, general feeling of being unwell
• increased energy or activity, unusual breathing pattern If any symptoms persist or you experience any other side effects please tell your doctor or pharmacist. It will help if you make a note of what you experienced, when it started and how long it lasted.

Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly (see details below). By reporting side effects you can help provide more information on the safety of this medicine. United Kingdom: Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. Ireland: HPRA Pharmacovigilance, Earlsfort Terrace, IRL – Dublin 2; Tel: +353 1 6764971; Fax: +353 1 6762517. Website: www.hpra.ie; E-mail:[email protected]

How to Store Sinemet CR

Keep out of the sight and reach of children
• Do not store above 30°C. Store in the original package in order to protect from light.
• Do not use Sinemet CR or Half Sinemet CR after the expiry date which is stated on the blister and carton after ‘EXP.’ The expiry date refers to the last day of that month.
• Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

Fast Shipping

Fast Shippings

2 to 3 weeks on average

The average shipping time is 2 weeks in North America and 4 weeks internationally. We offer free shipping on all orders shipped to North America. Shipping is a flat rate of $20.00 for all other countries.

Price Match Guarantee

Price Match Guarantees

If you have been prescribed medication by your doctor and cannot afford the high price at your local pharmacy, Medix Pharmacy is the solution for you. All orders are backed with a price match and satisfaction guarantee.

Your Trusted Pharmacy Referral Service

Medix Pharmacy is an international pharmacy referral service. With a network of licensed pharmacy partners in Canada, United Kingdom, Australia, and New Zealand, we are able to help you lower the costs of your medications.

Our pharmacy partners are all thoroughly vetted and qualified to ensure that the medication you receive is cost effective, safe and effective. Because we only work with licensed pharmacies, you can rest assured that your medication is safe, effective, and genuine.

  • Free standard delivery to your door, to any international address
  • Option to add Tracked Deliveries
  • Handy reminders to re-order so you do not run out
  • Professional & Knowledgeable Customer Services Team
  • Save time, with no need for repeated trips to your physician or local drugstore

With a dedicated customer service team, free standard shipping, and a record of providing significant saving for our customers, we believe that you do not need to compromise quality or safety in your search for value.

If you are unable to find your prescribed medicine on our website, please fill out the form below and we will confirm pricing and availability within 1 business day. You may also call us at 1-866-500-6633 and one of our patient care representatives will be happy to assist you.