Shipping Update - May 1 2022

Shipping times are now closer to normal. However, due to the latest outbreak of the highly contagious Omicron strain, some delays in shipping times may still occasionally occur. We will provide updates as the situation changes.

Our normal shipping time averages 1 - 2 weeks. Shipments may sometimes take an additional 2 weeks to arrive, depending on the source country of your order.

Please note that these times are averages and individual shipping times will vary. We recommend that you place your order at least 2 - 4 weeks or more ahead of your normal reorder time to avoid running out of your medication.

We offer a shipping guarantee when you place an order with us. If your order does not arrive within 6 weeks from the date it was shipped, we will re-ship your order to you at no additional cost.

Call Center - New Hours effective April 1, 2022

Our call center hours of operation are now 6:00 am - 9:00 pm Central Time on Monday to Friday, and 7:00 am - 7:00 pm Central Time on Saturday and Sunday.

If you are experiencing increased hold times or are calling outside of these hours, please leave us a message or send us an email and we will get back to you as soon as we can. Due to increased demand on telephone networks worldwide, you may experience some intermittent connection problems. If this happens our agents will call you back.

Our Commitment

If you have any questions about any changes in our service please do not hesitate to contact us. Our staff are working tirelessly to ensure the timely fulfillment and delivery of all orders. The health and safety of our customers and staff is our highest priority and we remain committed to providing service at the highest level.

We appreciate your business and thank you for your continued support.

Management and Staff
Medix Pharmacy


Prescription Settings Edit

Brand Name Choices

Vagifem 10mcg
Vagifem 10mcg Vaginal Tablets


Manufactured by Novo Nordisk Ltd

Product of Turkey

Dispensed by an international pharmacy partner

* Please note that Vagifem tablets are for vaginal use and not for oral use.

Prescription Required

Vagifem 10mcg
Vagifem 10mcg Vaginal Tablets


Manufactured by Novo Nordisk Ltd

Product of United Kingdom

Dispensed by a licensed pharmacy in the United Kingdom

* Please note that Vagifem tablets are for vaginal use and not for oral use.

Prescription Required

Parallel Import

Vagifem 10mcg
Vagifem 10mcg Vaginal Tablets


Manufactured by Novo Nordisk Canada Inc

Product of Canada

Dispensed by an approved Canadian pharmacy partner

* Please note that Vagifem tablets are for vaginal use and not for oral use.

Prescription Required

More Brand Name Choices

Generic Choices

Estradiol 10mcg
Estradiol 10mcg Vaginal Tablets

Generic Equivalent of Vagifem 10mcg

Manufactured by Various UK Generic Manufacturers (MHRA Approved)

Product of United Kingdom

Dispensed by a licensed pharmacy in the United Kingdom

* Please note that while the brand versions of Vagifem are supplied with individual pre-filled applicators, this UK generic version is supplied with one applicator. Each tablet will need to be loaded inside the supplied applicator. These tablets are for vaginal use and not for oral use.

Prescription Required

What Vagifem is and what it is used for

Vagifem® contains estradiol
• Estradiol is a female sex hormone.
• It belongs to a group of hormones called oestrogens.
• It is exactly the same as the estradiol produced by the ovaries of women. Vagifem® belongs to a group of medicines called vaginal Hormone Replacement Therapy (HRT). It is used to relieve menopausal symptoms in the vagina such as dryness or irritation. In medical terms this is known as ‘vaginal atrophy’. It is caused by a drop in the levels of oestrogen in your body. This happens naturally after the menopause Vagifem® works by replacing the oestrogen which is normally produced in the ovaries of women. It is inserted into your vagina, so the hormone is released where it is needed. This may relieve discomfort in the vagina. The experience of treating women older than 65 years is limited.

How to take Vagifem

Always use this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure. Using this medicine
• You can start using Vagifem® on any day which is best for you.
• Insert the vaginal tablet into your vagina with the applicator. The ‘USER INSTRUCTIONS’ at the end of the leaflet tell you how to do this. Read the instructions carefully before using Vagifem®. How much to use
• Use one vaginal tablet each day for the first 2 weeks.
• Then use one vaginal tablet twice a week. Leave 3 or 4 days between each dose. General information about treating symptoms of the menopause For OTC-products
• When using medicines for any menopausal symptoms, it is recommended to use the lowest dose that works, and to use the medicine for as short a time as it is needed. For prescription only products
• Your doctor will aim to prescribe the lowest dose of Vagifem® to treat your symptom for as short as necessary. Speak to your doctor if you think this dose is too strong or not strong enough.
• Treatment should only be continued if the benefit is greater than the risk. Talk to your doctor about this. If you use more Vagifem® than you should
• If you have used more Vagifem® than you should, talk to a doctor or pharmacist.
• Vagifem® is for local treatment inside the vagina. The dose of estradiol is so low that a considerable number of tablets would have to be taken to approach the dose normally used for treatment taken by mouth. If you forget to use Vagifem®
• If you forget a dose, use the medicine as soon as you remember.
• Do not use a double dose to make up for a forgotten dose. If you stop using Vagifem® Do not stop using Vagifem® without talking to your doctor. Your doctor will explain the effects of stopping treatment. He or she will also discuss other possibilities for treatment with you. If you need to have surgery If you are going to have surgery, tell the surgeon that you are using Vagifem®. You may need to stop using Vagifem® about 4 to 6 weeks before the operation to reduce the risk of a blood clot (see section 2, ‘Blood clots in a vein’). Ask your doctor when you can start using Vagifem® again. If you have any further questions on the use of this medicine, ask your doctor or pharmacist

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. The following diseases are reported more often in women using HRT medicines which circulate in the blood compared to women not using HRT. These risks apply less to vaginally administered treatments such as Vagifem®:
• breast cancer;
• ovarian cancer;
• blood clots in the veins of the legs or lungs (venous thromboembolism);
• stroke;
• probable memory loss if HRT is started over the age of 65; For more information about these side effects, see section 2, ‘What you need to know before you use Vagifem®’.

Common: may affect up to 1 in 10 people
• Headache
• Stomach pain
• Vaginal bleeding, discharge or discomfort.

Uncommon: may affect up to 1 in 100 people
• An infection of the genitals caused by a fungus
• Feeling sick (nausea)
• Rash
• Weight increase
• Hot flush
• Hypertension.

Very rare: may affect up to 1 in 10,000 people
• Diarrhoea
• Fluid retention
• Migraine aggravated
• Generalised hypersensitivity (e.g. anaphylactic reaction/shock).

The following side effects have been reported with systemic oestrogen treatment:
• Gall bladder disease
• Various skin disorders:
•discoloration of the skin especially of the face or neck known as ‘pregnancy patches’ (chloasma)
•painful reddish skin nodules (erythema nodosum)
•rash with target-shaped reddening or sores (erythema multiforme).

Reporting of side effects If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the Yellow Card Scheme Website: or search for MHRA Yellow Card in the Google Play or Apple App Store. By reporting side effects you can help provide more information on the safety of this medicine.

How to Store Vagifem

Keep this medicine out of the sight and reach of children. Do not refrigerate. Do not use this medicine after the expiry date which is stated on the carton label and blister after EXP. The expiry date refers to the last day of that month. Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment. This medicine may cause risk to the aquatic environment.

Related Products

Fast Shipping

Fast Shippings

2 to 3 weeks on average

The average shipping time is 2 weeks in North America and 4 weeks internationally. We offer free shipping on all orders shipped to North America. Shipping is a flat rate of $20.00 for all other countries.

Price Match Guarantee

Price Match Guarantees

If you have been prescribed medication by your doctor and cannot afford the high price at your local pharmacy, Medix Pharmacy is the solution for you. All orders are backed with a price match and satisfaction guarantee.

Your Trusted Pharmacy Referral Service

Medix Pharmacy is an international pharmacy referral service. With a network of licensed pharmacy partners in Canada, United Kingdom, Australia, and New Zealand, we are able to help you lower the costs of your medications.

Our pharmacy partners are all thoroughly vetted and qualified to ensure that the medication you receive is cost effective, safe and effective. Because we only work with licensed pharmacies, you can rest assured that your medication is safe, effective, and genuine.

  • Free standard delivery to your door, to any international address
  • Option to add Tracked Deliveries
  • Handy reminders to re-order so you do not run out
  • Professional & Knowledgeable Customer Services Team
  • Save time, with no need for repeated trips to your physician or local drugstore

With a dedicated customer service team, free standard shipping, and a record of providing significant saving for our customers, we believe that you do not need to compromise quality or safety in your search for value.

If you are unable to find your prescribed medicine on our website, please fill out the form below and we will confirm pricing and availability within 1 business day. You may also call us at 1-866-500-6633 and one of our patient care representatives will be happy to assist you.