(Doxycycline Hyclate)

Prescription Settings Edit

Brand Name Choices

Periostat 20mg
Periostat 20mg

Doxycycline Hyclate

Manufactured by Alliance Pharmaceuticals Ltd

Product of United Kingdom

Dispensed by a licensed pharmacy in the United Kingdom

Prescription Required

Parallel Import

Generic Choices

No generic medication is available for Periostat (Doxycycline Hyclate)

What Periostat is and what it is used for

Periostat belongs to a group of medicines called tetracyclines. Tetracyclines are a type of antibiotic although the very small dose of doxycycline contained in Periostat is not high enough for Periostat to act as an antibiotic. Periostat tablets are used in the treatment of periodontitis (a condition of the gums which can cause teeth to become loose or fall out). The standard treatment for periodontitis is a scaling and root planing carried out by your dentist or dental hygienist. Periostat is then prescribed by your dentist as an additional treatment. The oral hygiene routine explained by your dentist or dental hygienist should continue at the same time. The periodontium, which is made up of collagen fibres, is the part of the gum that gives support to each tooth and it is this part that is affected by periodontitis. Periodontitis is caused by the presence of bacteria at the gum line which can cause inflammation and infection of the gum. The body’s immune system makes special cells to fight the gum infection. The body releases enzymes into the gums which break down the collagen fibres around the tooth and allows these special cells to get to the site of infection. Unfortunately, although the enzymes are part of the body’s own defence system, they actually damage the gum. This can cause teeth to become loose or even fall out. Diagram 1 Periostat Tabs PIL UK 008 explains the causes of periodonitis. Diagram 1: The causes of periodontitis Plaque and bacteria The body releases The enzymes destroy accumulate on the enzymes into the the tissues supporting tooth near the gum gum the tooth Periostat reduces the effect of the collagenase enzymes. This can make your gums healthier and increase the stability of your affected teeth. Diagram 2 explains how scaling and root planing with the addition of Periostat treats periodontitis.

How to take Periostat

Always take Periostat exactly as your dentist has told you to. You should check with your dentist, doctor or pharmacist if you are not sure. Periostat Tabs PIL UK 008 The usual dose is one tablet in the morning and one in the evening. Periostat should be taken at least one hour before going to bed for the night and at least one hour before meals. Try and take the medication at the same times each day. The tablets should be swallowed with a drink of water in the sitting or standing position followed by plenty of fluid. Do not lie down immediately after taking the tablet. Periostat is usually taken for a minimum of 3 months and can be taken for up to 9 months at a time. It is important that you continue to take Periostat until your dentist tells you to stop. What to do if you take more Periostat than you should If you accidentally take too many tablets, or someone else takes any of your medicine, you should tell your doctor at once or contact the nearest accident and emergency department. Show any left-over medicines or the empty packet to the doctor. If you forget to take Periostat Do not worry. If you forget to take a dose, just take the next dose as normal. DO NOT take a double dose. Then go on as before. If you stop taking Periostat Complete the prescribed course unless otherwise directed by your dentist or doctor. If you have any further questions on the use of this product, ask your dentist, doctor or pharmacist.

Possible side effects

Like all medicines, Periostat can cause side effects, although not everybody gets them. If any of the side effects listed below occur, contact your doctor as soon as possible:
• you have a severe allergic reaction which includes sudden wheeziness, chest pain, difficulty in breathing, sudden swelling, fever, skin rash or itching (see Section 2 Check before you take Periostat)
• you have severe headaches together with disturbed vision. This may mean you have increased pressure in the brain
• you have diarrhoea which is watery or contains blood (see Section 2 Check before you take Periostat)
• you suspect you have a problem with your liver (this may cause yellowing of the skin or whites of the eyes and/or severe stomach pains) (see Section 2 Check before you take Periostat).
• you have Stevens-Johnson syndrome (a serious illness which causes blistering of the skin, lining of the mouth, throat, eyes and genitals). Periostat Tabs PIL UK 008
• the Jarisch-Herxheimer reaction which causes fever, chills, headache, muscle pain, and skin rash that is usually self-limiting. This occurs shortly after starting doxycycline treatment for infections with spirochete such as Lyme disease.

Other side effects are:

Very common side effects (more than 1 in 10 patients) of Periostat include:
• headache
• common cold
• flu like symptoms (such as fever).

Common side effects (more than 1 in 100 patients) of Periostat include:
• acid indigestion (heartburn)
• feeling sick
• diarrhoea
• indigestion
• rash
• sinusitis (inflammation of the nasal passages), coughing and bronchitis
• tooth abscess
• sore throat and sinus headache
• toothache, pain of any sort, joint and back pain
• period pains
• infection (e.g. thrush).

Uncommon side effects (more than 1 in 1000 patients) of Periostat include:
• muscle and gum pain
• flaking or peeling of the skin.

Rare side effects (more than 1 in 10,000 patients) of Periostat include:
• vaginal and anal thrush (causing soreness and/or itching of the rectal and/or genital area) and oral thrush (causing pale patches at the corner of your mouth)

Very rare side effects of Periostat include:
• dizziness
• stomach pain, constipation, dry mouth and temporary tooth discolouration
• colitis (inflammation of the intestines which can cause stomach pain, diarrhoea and other symptoms) and pseudomembranous colitis (infection of the intestines which can cause stomach pain, fever and diarrhoea)
• your skin becoming sensitive to sunlight
• weakness
• itching.

Other side effects that have occurred in people taking other tetracyclines similar to Periostat are:
• Blood disorders. These are due to an imbalance in numbers of different cell types in the blood. Symptoms may include tiredness, easy bruising, nose bleeds or susceptibility to infection.
• Lack or loss of appetite, inflammation of the tongue and difficulty in swallowing. Periostat Tabs PIL UK 008
• Inflammation and/or ulcers of the gullet (food pipe). This can be avoided by taking Periostat in an upright position with water (see Section 3 How to take Periostat).
• Increase in blood urea (this is detected by a blood test).
• If you suffer from a disease called systemic lupus erythematosus (SLE), an allergic condition which causes joint pain, skin rashes and fever you may notice your condition gets worse.
• separation or loosening of a fingernail or toenail from its nail bed following exposure to sunlight or ultraviolet rays. If any of the side effects gets worse, or if you notice any side effects not listed in this leaflet, please tell your dentist, doctor or pharmacist. You can also report side effects directly via the internet at or call Freephone 0808 100 3352. By reporting side effects you can help provide more information on the safety of this medicine.

How to Store Periostat

Keep out of the reach and sight of children. Do not use Periostat after the expiry date {EXP mm yyyy} which is stated on the white container or blister pack. The expiry date refers to the last day of that month.Do not store above 25ºC. Do not remove the tablets from the container or blister pack until you are ready to take the medicine. When tablets are supplied in a white container, always ensure the desiccant is returned to the container, and the container tightly closed after each dose is removed. Do not swallow the desiccant, and should this occur, contact your dentist or doctor immediately. Do not take Periostat if you notice the appearance of the tablets has changed in any way. Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

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